Prof Bruce Biccard

Prof  Bruce Biccard

Person

Prof  Bruce Biccard

Telephone

RESIGNED

Email

RESIGNED

Campus /Hospital

School of Clinical Medicine/ Inkosi Albert Luthuli Hospital

Research Interests

Perioperative risk prediction, risk modification and outcomes research

Designation

Honorary Associate Professor

 Bio sketch Bruce Biccard is an anaesthesiologist and Honorary Associate Professor at the University of Kwazulu-Natal. His principle area of practice is vascular anaesthesia. His research interests include the epidemiology of cardiovascular disease, perioperative cardiovascular risk prediction and risk modification, perioperative medicine and surgical outcomes. He is the Director of the Perioperative Research Group, Department of Anaesthetics, Nelson R Mandela School of Medicine, where national and international collaborative cardiovascular research is conducted.

ResearchGate Profile

 List of Publications  

  1. Peer reviewed journals  
  1. Biccard BM, Devereaux PJ, Rodseth RN. Cardiac biomarkers in the prediction of risk in the non-cardiac surgery setting. Anaesthesia 2014; 69: 484-93.
  2. Devereaux PJ, Sessler DI, Leslie K, Kurz A, Mrkobrada M, Alonso-Coello P, et al. Clonidine in Patients Undergoing Noncardiac Surgery. N Engl J Med 2014. [10.1056/NEJMoa1401106] [PMID: 24679061]
  3. Devereaux PJ, Mrkobrada M, Sessler DI, Leslie K, Alonso-Coello P, Kurz A, et al. Aspirin in Patients Undergoing Noncardiac Surgery. N Engl J Med 2014. [10.1056/NEJMoa1401105] [PMID: 24679062]
  4. Biccard BM, Madiba TE. Announcement of the South African Surgical Outcomes Study (SASOS). Southern African Journal of Anaesthesia and Analgesia 2014;20(1):6-7.
  5. Biccard BM, Rodseth RN. Taking an idea to a research protocol. Southern African Journal of Anaesthesia and Analgesia 2014;20(1):14-18.
  6. Biccard BM. Myocardial injury after non-cardiac surgery: a new clinical entity. Southern African Journal of Anaesthesia and Analgesia 2014;20(1):24.
  7. Garg AX, Kurz A, Sessler DI, Cuerden M, Robinson A, Mrkobrada M, et al. Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial. BMJ Open 2014;4(2):e004886.
  8. Redman LA, Naidoo P, Biccard BM. HIV, vascular surgery and cardiovascular outcomes: a South African cohort study. Anaesthesia 2014;69(3):208-13.
  9. Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, et al. Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes. Anesthesiology 2014;120(3):564-78.
  10. Roberts
  11. Moyce Z, Rodseth RN, Biccard BM. The efficacy of peri-operative interventions to decrease postoperative delirium in non-cardiac surgery: a systematic review and meta-analysis. Anaesthesia 2014;69(3):259-69.
  12. Moodley Y, Naidoo P, Biccard BM. The South African Vascular Surgical Cardiac Risk Index (SAVS-CRI): A prospective observational study. S Afr Med J 2013;103(10):746-50.
  13. Rodseth RN, Biccard BM, Le Manach Y, Sessler DI, Lurati Buse GA, Thabane L, et al. The prognostic value of preoperative and postoperative B-type natriuretic peptides (BNP and NT proBNP) in patients having noncardiac surgery: A systematic review and individual patient data meta-analysis. J Am Coll Cardiol 2013.
  14. Harilall Y, Adam JK, Biccard BM, Reddi A. The Effect of Optimising Cerebral Tissue Oxygen Saturation on Markers of Neurological Injury during Coronary Artery Bypass Graft Surgery. Heart Lung Circ 2013.
  15. Rodseth RN, Biccard BM, Chu R, Lurati Buse GA, Thabane L, Bakhai A, et al. Postoperative B-type natriuretic peptide for prediction of major cardiac events in patients undergoing noncardiac surgery: systematic review and individual patient meta-analysis. Anesthesiology 2013;119(2):270-83.
  16. Biccard BM, Rodseth RN. What evidence is there for intraoperative predictors of perioperative cardiac outcomes? A systematic review. Perioper Med (Lond) 2013;2(1):14.
  17. Minto G, Biccard BM. Assessment of the high-risk perioperative patient. Continuing Education in Anaesthesia, Critical Care & Pain 2013; 10.1093/bjaceaccp/mkt020.
  18. Biccard BM. Anaesthesiology and research in South Africa: a proposal for a national collaborative anaesthesiology research group. Southern African Journal of Anaesthesia and Analgesia 2013;19(2):89-94.
  19. Afshani N, Moustaqim-Barrette A, Biccard BM, Rodseth RN, Dyer RA. Utility of B-type natriuretic peptides in preeclampsia: a systematic review. Int J Obstet Anesth 2013; 22: 96-103.
  20. Rodseth RN, Vasconcellos K, Naidoo P, Biccard BM. Preoperative B-type natriuretic peptide risk stratification: do postoperative indices add value? Southern African Journal of Anaesthesia and Analgesia 2013; 19: 60-65.
  21. Afshani N, Biccard BM, Dyer RA. The role of biomarkers and B-type natriuretic peptide in diagnosis and perioperative risk prediction. Southern African Journal of Anaesthesia and Analgesia 2012; 18: 303-308.
  22. Naidoo T, Konkol K, Biccard B, Dudose K, McKune AJ. Elevated salivary C-reactive protein predicted by low cardio-respiratory fitness and being overweight in African children. Cardiovasc J Afr 2012; 23: 501-506.
  23. Sheth T, Butler C, Chow B, et al. The coronary CT angiography vision protocol: a prospective observational imaging cohort study in patients undergoing non-cardiac surgery. BMJ Open 2012; 2.
  24. Skinner DL, Goga S, Rodseth RN, Biccard BM. A meta-analysis of intraoperative factors associated with postoperative cardiac complications. Southern African Journal of Anaesthesiology and Analgesia 2012; 18: 186-91.
  25. Dyer RA, Biccard BM. Ephedrine for spinal hypotension during elective caesarean section: the final nail in the coffin? Acta Anaesthesiol Scand 2012; 56: 807-9.
  26. Devereaux PJ, Chan MT, Alonso-Coello P, et al. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA 2012; 307: 2295-304.
  27. Biccard BM, Naidoo P, de Vasconcellos K. What is the best pre-operative risk stratification tool for major adverse cardiac events following elective vascular surgery? A prospective observational cohort study evaluating pre-operative myocardial ischaemia monitoring and biomarker analysis. Anaesthesia 2012; 67: 389-95.
  28. Drummond L, Biccard BM. Statins in cardiac surgery. Southern African Journal of Anaesthesia and Analgesia 2012; 18: 56.
  29. Biccard BM. Postoperative risk stratification for cardiovascular events. Southern African Journal of Anaesthesia and Analgesia 2012; 18: 54-5.
  30. Biccard BM. Predicting outcome. Southern African Journal of Anaesthesia and Analgesia 2012; 18: 52.
  31. Biccard BM. Surgery and cardiovascular outcomes: an untapped public health benefit that potentially saves lives. Anaesthesia 2012; 67: 106-9.
  32. Biccard BM, Lurati Buse GA, Burkhart C, Cuthbertson BH, Filipovic M, Gibson SC, Mahla E, Leibowitz DW, Rodseth RN. The influence of clinical risk factors on pre-operative B-type natriuretic peptide risk stratification of vascular surgical patients. Anaesthesia 2012; 67:55-9
  33. Ryan L, Rodseth RN, Biccard BM. The treatment of perioperative myocardial infarctions following noncardiac surgery. Southern African Journal of Anaesthesia and Analgesia 2012;18(2):86-93.
  34. Ryan L, Rodseth RN, Biccard BM. Peri-operative myocardial infarction: time for therapeutic trials. Anaesthesia 2011; 66: 1083-7.
  35. Biccard BM, Rodseth RN. Utility of clinical risk predictors for preoperative cardiovascular risk prediction. Br J Anaesth. 2011 Aug;107(2):133-43.
  36. Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, et al. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study. Clin Biochem. 2011 Aug;44(12):1021-4.
  37. Redfern G, Rodseth RN, Biccard BM. Outcomes in vascular surgical patients with isolated postoperative troponin leak: a meta-analysis. Anaesthesia 2011;66:604-10.
  38. Biccard BM, Naidoo P. The role of brain natriuretic peptide in prognostication and reclassification of risk in patients undergoing vascular surgery. Anaesthesia. 2011, 66: 379-85.
  39. Rodseth RN, Lurati Buse GA, Bolliger D, Burkhart CS, Cuthbertson BH, Gibson SC, et al. The predictive ability of pre-operative B-type natriuretic Peptide in vascular patients for major adverse cardiac events an individual patient data meta-analysis. J Am Coll Cardiol. 2011 Jul 26;58(5):522-9.
  40. Harilall Y, Adam JK, Biccard BM, Reddi A. Correlation between cerebral tissue and central venous oxygen saturation during off -pump coronary bypass graft surgery. Perfusion. 2011, 26: 83-90.
  41. Biccard BM, Kassanjee R, Welte A. Is it possible to decrease the incidence of peri-operative stroke associated with acute peri-operative beta-blocker administration? Anaesthesia. 2011;66:80-3.
  42. Semark A, Rodseth RN, Biccard BM. When is the risk acceptable to proceed to noncardiac surgery following an acute myocardial infarction? Minerva Anestesiol. 2011;77:64-73.
  43. Biccard BM, Nepaul S. Risk factors associated with intermediate and long-term mortality following vascular surgery in South African patients. Cardiovasc J Afr. 2010;21:263-7.
  44. Biccard BM, Rodseth RN. The pathophysiology of perioperative myocardial infarction. Anaesthesia 2010; 65 (7): 733-41
  45. Biccard BM. Factors associated with mortality when chronic beta-blocker therapy is withdrawn in the peri-operative period in vascular surgical patients: a matched case–control study. Cardiovascular Journal of Africa 2010; 21 (2): 97-102
  46. Rodseth RN, Biccard BM. Living longer as an anaesthetist: The ‘magic’ lifestyle or the ‘lifestyle polypill’. SAJAA 2009; 15 (4): 5-10
  47. Biccard BM, Rodseth RN. A meta-analysis of the prospective randomised trials of coronary revascularisation before noncardiac vascular surgery with attention to the type of coronary revascularisation performed. Anaesthesia 2009, 64: 1105-1113.
  48. Biccard BM. Investigation of predictors of increased creatine kinase levels following vascular surgery and the association with peri-operative statin therapy. Cardiovasc J Af;, 2009; 20: 187-91.
  49. Mulaudzi TV, Biccard BM, Robbs JV, Paruk N, Pillay B, Rajaruthnam P. Carotid artery stump pressure and associated neurological changes in predominantly symptomatic carotid artery disease patients undergoing awake carotid endarterectomy. Cardiovasc J Afr 2009;20(2):116-8.
  50. Padayachee L, Rodseth RN, Biccard BM. A meta-analysis of the utility of C-reactive protein in predicting early, intermediate-term and long term mortality and major adverse cardiac events in vascular surgical patients. Anaesthesia 2009;64(4):416-24.
  51. Biccard BM, Pooran R. Validation of a model to predict all-cause in-hospital mortality in vascular surgical patients. Cardiovascular Journal of Africa 2008; 19 (6): 303-308
  52. Biccard BM, Howell SJ. Calcium channel blockers, beta-blockers, and perioperative cardiovascular stability. Br J Anaesth 2008;101(4):439-41.
  53. Biccard BM. Beta-Blockers for non-cardiac surgery: a different approach after the poise data or await more information? Rev Assoc Med Bras 2008;54(4):296.
  54. Biccard, BM. Heart rate and outcome in patients with cardiovascular disease undergoing major noncardiac surgery. Anaesth Intensive Care 2008;36(4):489-501.
  55. Myers SD, Biccard BM, Chan C, Imray CH, Wright AD, Pattinson KT. Delayed Acclimatization of the Ventilatory Threshold in Healthy Trekkers. Wilderness Environ Med 2008; 19 (2): 124-128.
  56. Rodseth RN, Padayachee L, Biccard BM. A meta-analysis of the utility of pre-operative brain natriuretic peptide in predicting early and intermediate-term mortality and major adverse cardiac events in vascular surgical patients. Anaesthesia 2008; 63: 1226-33.
  57. Howard-Alpe G, Foëx P, Biccard B. Cardiovascular protection by anti-inflammatory statin therapy. Best Pract Res Clin Anaesthesiol. 2008; 22 (1): 111-33. (To be put into IRMA)
  58. Biccard BM. Should I anaesthetise this patient? Rational cardiovascular assessment. Continuing Medical Education 2008; 26 (3): 130-3
  59. Biccard BM. Anaesthesia for vascular procedures: how do South African patients differ? SAJAA 2008; 14 (1): 109-115
  60. Biccard BM, Goga S, de Beurs J. Dexmedetomidine and cardiac protection for noncardiac surgery: a meta-analysis of randomised controlled trials. Anaesthesia 2008; 63 (1): 4-14
  61. Biccard BM. A peri-operative statin update for non-cardiac surgery. Part 2 Statin therapy for vascular surgery and peri-operative statin trial design. Anaesthesia 2008; 63 (2): 162-71
  62. Biccard BM. A peri-operative statin update for non-cardiac surgery. Part 1 The effects of statin therapy on atherosclerotic disease and lessons learnt from statin therapy in medical (non-surgical) patients. Anaesthesia 2008; 63 (1): 52-64
  63. Biccard BM, Sear JW, Foex P. Meta-analysis of the effect of heart rate achieved by perioperative beta-adrenergic blockade on cardiovascular outcomes. Br J Anaesth 2008; 100 (1): 23-28
  64. Biccard BM, Bandu R. Clinical risk predictors associated with cardiac mortality following vascular surgery in South African patients. Cardiovascular Journal of Africa 2007; 18 (4): 216-20
  65. Biccard BM, Sear JW, Foëx P. Are lipophilic beta-blockers preferable for peri-operative cardioprotection? Implications from a limited systematic review of the efficacy of atenolol and metoprolol in preventing in-hospital ventricular fibrillation following acute myocardial infarction. SAJAA 2006; 12 (4): 141-146
  66. Biccard BM, Sear JW, Foëx P. Acute peri-operative beta-blockade in intermediate-risk patients. Anaesthesia 2006; 61: 924-31.
  67. Biccard BM, Sear JW, Foëx P. The pharmaco-economics of peri-operative beta-blocker and statin therapy in South Africa. South African Medical Journal, 2006; 96 (11): 1199-1202.
  68. Biccard BM. Acute peri-operative beta-blockade in South Africa. SAJAA 2006; 12 (1): 32-4
  69. Biccard BM, Sear JW, Foëx P. A reply. Statin therapy: a potentially useful peri-operative intervention in patients with cardiovascular disease. Anaesthesia 2006; 61: 308
  70. Biccard BM, Sear JW, Foëx P. The pharmaco-economics of peri-operative beta-blocker therapy. Anaesthesia 2006; 61: 4-8 (Pharmaco-economic analysis)
  71. Biccard BM, Sear JW, Foëx P. Statin therapy: a potentially useful peri-operative intervention in patients with cardiovascular disease. Anaesthesia 2005; 60: 1106-14 (Review)
  72. Biccard BM, Sear JW, Foëx P. The pharmaco-economics of peri-operative statin therapy.  Anaesthesia 2005; 60: 1059-63 (Pharmaco-economic analysis)
  73. Biccard BM. Relationship between the inability to climb two flights of stairs and outcome after major non-cardiac surgery: implications for the pre-operative assessment of functional capacity. Anaesthesia 2005; 60: 588-593 (Review)
  74. Biccard BM. Awake carotid endarterectomy to decrease stroke rate in high-risk patients: case report. SAJAA 2004; 10: 19-20 (Case report)
  75. Biccard BM. A response to ‘Perioperative b-blockade and haemodynamic optimisation in patients with coronary artery disease and decreasing exercise capacity presenting for major non-cardiac surgery’. Anaesthesia 2004; 59: 521-522 (Correspondence)
  76. Biccard BM. Perioperative b-blockade and haemodynamic optimisation in patients with coronary artery disease and decreasing exercise capacity presenting for major non-cardiac surgery. Anaesthesia 2004; 59: 60-68 (Review)
  77. Biccard BM. Perioperative b-adrenoceptor blockade in major non-cardiac surgery. SAJAA 2002; 8 (5): 30-5 (Review)
  78. Biccard BM, Gopalan PD. Phaeochromocytoma and acute myocardial infarction.
    Anaesth Intensive Care. 2002; 30 (1): 74-6 (Case report)
  79. Biccard BM, Hughes M. Succinylcholine in the intensive care unit. Anesthesiology. 2002; 96 (1): 253-4 (Letter)
  80. Biccard, B. Ropivacaine is not the S-isomer of bupivacaine. Can J Anaesth. 2001; 48 (11): 1170-1 (Letter)
  81. Biccard BM. EMLA-1 h is not enough for venous cannulation. Anaesthesia. 2001; 56 (10): 1027-8 (Letter)
  82. Biccard BM. Phaeochromocytoma: an unusual cause of hypertension in pregnancy.
    Anaesthesia. 2001; 56 (7): 706-7 (Letter)
  83. Hughes M, Grant IS, Biccard B, Nimmo G. Suxamethonium and critical illness polyneuropathy. Anaesth Intensive Care. 1999; 27 (6): 636-8 (Postal survey)
  84. Biccard BM, Grant IS, Wright DJ, Nimmo SR, Hughes M. Suxamethonium and critical illness polyneuropathy. Anaesth Intensive Care. 1998; 26 (5): 590-1 (Letter) 
  1. Book Chapters 
  1. Foëx P, Biccard BM. Stunning, hibernation, preconditioning, postconditioning and the effects of anaesthetic agents. In: Heart disease and the surgical patient. Editor Howell SJ, Spahn DR, Pepper. Marcel Dekker 2006. ISBN 978-0-8493-4091-8
  2. Beattie C, Biccard BM. Reducing perioperative cardiac risk. In: Moores C and Nimmo A, eds. Core topics in vascular anaesthesia. Cambridge: Cambridge University Press, 2012: 32-47. ISBN 9781107001817
  3. Nienaber LN, Biccard BM. Autonomic nervous system. In: Milner A, Welch E, eds. Applied pharmacology in anaesthesiology and critical care. Centurion: Medpharm Publications, 2012: 145-196. ISBN 978-0-620-53726-1
  4. Rantloane JLA, Brandl AB, Biccard BM. Premedication. In: Milner A, Welch E, eds. Applied pharmacology in anaesthesiology and critical care. Centurion: Medpharm Publications, 2012: 382-416. ISBN 978-0-620-53726-1